Abstract: To understand the spatial-temporal evolution law of the permeability coefficient of ore aquifers in the process of uranium leaching by the acid method, a two-dimensional reaction dynamics model consisting of two sets of five-point dip extraction wells was established through numerical simulation. The temporal-spatial evolution process of the porosity-permeability coefficient in urannium leaching by the acid method was simulated to discuss the temporal and spatial evolution law of the permeability coefficient of ore-bearing aquifers. At the end of the simulation, the interval of the permeability coefficient in the simulation area is 5.37 m/d, 14.7 m/d. It can be seen from the results of the time evolution of the permeability coefficient that, with the front of the seepage effect and chemical reaction continuously advancing toward the extracting hole, the area where the permeability coefficient changes and the interval value of the permeability coefficient in the simulation area increase over time. The evolution of the permeability coefficient around the six injection holes varies slightly at the end of the simulation. The area where the permeability coefficient of the ore layer is greater than the initial value is in the cylinder approximately 3 m to the center of the injection hole (accounting for 1/10 radius of the injection radius). The minimum permeability coefficient value appears on the circumference approximately 5.66 m away from the center of the injection hole. The permeability coefficient of most areas of the aquifer is less than the initial value. According to the simulation results, the minimum value of the permeability coefficient may occur in the region between 1/6 and 1/5 of the pumping and injecting radius away from the injection hole.