Abstract: From the perspective of safety management in production, mining enterprises face grave challenges. The enterprises have higher likelihood of workplace accidents than other enterprises, and safety management in production utterly falls behind. Targeted education and training are adopted to improve all employees' ability to ensure workplace safety; physical isolation, listing, locking and so on are applied to improve the safety and reliability of equipment, as well as working environment. And relying on the current laws, regulations and standards, the construction of a targeted safety management system to improve the level of safety management is promoted. The system has four characteristics: safety and reliability of human, material, system, as well as management practices and continuous improvement. In other words, the system has an integral safety level of "human-machine-environment-management", with generalized intrinsic safety. By optimizing resource allocation, improving the system's integrity and reliability, the objective "zero accident" of safety management in production will be achieved.