Abstract: The characterization of warming compression ion-exchange separation technology and its superiority on preparing laser crystal rare earth exide compound were described in this article. The process of preparing 75N Ho₂O₃, Er₂O₃, Tm₂O₃, Yb₂O₃, Lu₂O₃ via micro-level exchange resin warming compression ion-exchange was also elaborated. The determining criteria of drenching the lotion, the retardant, column ratio column combination etc. were discussed in detail. The primary and auxiliary equipments of warming compression ion-exchange process to separate rare-earth elements were also illustrated.