Abstract: According to the complexity of lead -zinc polymetallic mineral and the similarity of lead, arsenic (arsenopyrite), zinc sulfide mineral, using interaction and synergy of combination depressants to strengthen the depressant and selectivity. The test add XY -3 inorganic compound depressant combined with lime, can drop lead and zinc concentrate containing the arsenic from the original 2% respectively to 0.6 percent and 0.3%.