Abstract: In this study, the zinc electrolysis anode slime with MnO₂ obtained as the main component at the zinc electrowinning process was used to oxidize the ferrous ions in the leaching solution of zinc calcine. The effects of reaction temperature, reaction time, stirring speed, particle size of anode slime and liquid-solid ratio on the oxidation ratio of ferrous ions were studied. The experimental results show that the oxidation ratio of ferrous ions reaches as high as 99.80 % under the optimal conditions of reaction temperature of 85 ℃, reaction time of 60 min, stirring speed of 500 r/min, anode mud particle size of 0.154 mm and liquid-solid ratio of 14∶1. This process not only makes full use of resources and reduces production costs but also solves the environmental problems caused by solid waste storage, achieving the efficient utilization of the electrolytic anode slime produced by zinc smelting enterprises.