Abstract: Taking the filling pipeline under a tin mine in Yunnan Province as the object, this article obtained the rheological parameters of the entire tailings of the mine through rheological experiments, and preliminarily calculated the resistance loss of the tailings slurry using the Buckingham equation. Finally, simulation calculations were conducted using ANSYS FLUENT software, and the simulation results were analyzed in depth. The research results indicate that the optimal solution is the C1 scheme, which means that the tailings slurry with a cement content of 300 kg/m³ and a mass concentration of 72% can be safely transported within the pipeline for over 2 600 meters, and the filling flow rate can reach 110 m³/h, which meets the filling requirements from the underground filling preparation station to various goaves in the mine and ensures the safe, reliable, and efficient operation of the filling system. Further research and analysis have found that the velocity and pressure of the tailings slurry transported in the pipeline have a boundary layer effect. The resistance loss of pipeline transportation increases with the increase of yield stress and viscosity of tailings slurry, and the relationship expression between resistance loss and yield stress and viscosity is obtained. This article develops a simple and efficient calculation, simulation, and analysis method for the reasonable and safe pipeline transportation of tailings slurry in the filling mining method, providing technical guidance for the practical application of the filling mining method.