Abstract: Rapid and effective evaluation of the slope stability of open pit mine slope has important theoretical significance and practical value to ensure the safety of construction equipment and personnel. In view of the complexity and uncertainty of the influencing factors on the slope stability of open-pit mines, the influence of subjective experience on the index weight, and the complexity and low efficiency of the evaluation model, an evaluation model for the slope stability of open-pit mines considering the change in the index weight is established according to the methods of information entropy and unascertained measure theory, which not only solves the problem of the uncertainty of the evaluation index data, but also take into consideration the dynamic change in evaluation index weight. On this basis, a set of intelligent evaluation systems for slope stability is developed by using windows form application development mode and C# programming language, avoiding the complex artificial calculation and improving work efficiency. With the slope of Yuebao open-pit mine as the research object, the results show that the stability evaluation results are basically consistent with the actual slope, which has strong practicability, reliability and feasibility.