Abstract: Mechanical activation is a clean, efficient and low energy-consuming preparation and strengthening technology that can improve the activity of solid materials, accelerate the reaction, and reduce reaction dependency on conditions, such as temperature and reagent dosage. The paper summarized the research of mechanical activation in solid phase reaction, including the principles of mechanical activation, the change of energy storage, the influence of mechanical activation on the properties of materials, and further briefly introduced its application. And it is instructive to the future research into the application of mechanical activation in solid state reaction.