Abstract: In the process of zinc hydrometallurgy, the silver in zinc concentrate is mainly concentrated in acid leaching residue. The grade of Ag in the leaching residue of this mineral sample is about 234 g/t, containing Zn, Pb and other reusable metals. Therefore, it is of great significance to study the recovery and reuse of Ag, Zn, Pb, etc. This paper studied the enrichment trend of Ag, Zn and Pb in the physical separation process and the influence of the amount of sodium chloride, roasting time and temperature on Ag leaching rate, through physical separation, reduction roasting, direct smelting and oxidation roasting and cyanidation of Ag from acid leaching residue. The results showed that Zn and Ag could be enriched by flotation after high temperature and high acid leaching. The Ag and Pb in crude lead were enriched and Ag grade was increased by 6 times after acid leaching. The optimum parameters of oxidation roasting and cyanide leaching for silver extraction were obtained by the experiments.