Abstract: After being mined for years, Wushan copper mine faces many problems, such as serious wind disturbance, requirement for more scattered vents, low single stage efficiency of fans, less fresh air flow in the mine's multi-sublevel. In order to solve these problems, the optimization scheme of the ventilation system is put forward and the ventilation simulation model of Wushan copper mine is established with the help of Ventsim software system. The model simulates air volume in easy ventilation period and in the difficult one, respectively. Using Ventsim system to find out the problems, the optimization scheme of ventilation network is put forward to solve the practical problems existing in the project.