Abstract: The MMS-100 thermal simulation tester was utilized to perform a single pass compression test on 5182 aluminium alloy, and its thermal denaturation behavior was studied to construct a model of flow stress and the processing map. The results showed that the flow stress of 5182 aluminium alloy gradually decreased with the increase in temperature and the decrease in strain rate. Moreover, high temperature would promote the occurrence of dynamic recrystallization, and the effect of strain rate could be ignored. The true stress-true strain curve of the alloy produced jagged undulations at high strain rates; there would be a high-power dissipation factor area when the true strain ε=0.4 at 420 ℃ to 500 ℃, and the strain rate to 0.1 s^-1. In addition, the alloy had a larger safe machining area when the temperature was near 450 ℃.