Abstract: Euler -Euler multiphase flow model, standard k-ε model and Multi-Reference Frame model (MRF) were applied to simulate the three-phase mixing system of H₂SO₄-O₂-copper anode slime in a vertical kettle. On the basis of orthogonal design experiments and grey analysis, this paper studies the effects of various factors, including stirring speed, sulfuric acid concentration, liquid-solid ratio and temperature, on the mixing performance and the scale of importance for these elements. The gas holdup rate, turbulent kinetic energy, liquid phase velocity, and solid phase velocity were used as comprehensive evaluation indicators. The results show that the correlation speed range of the agitation speed is the largest, that is, the rotational speed has the greatest influence on the mixing performance.The order of the factors affecting mixing performance is: stirring speed> temperature> sulfuric acid mass fraction> liquid-solid ratio.