Abstract: Flotation separation of drug is one of the most important and difficult part during the fluorite flotation. The types, mechanism and current situation of application of the fluorite flotation collector and adjusting agent were summarized to find out that clean, efficient and selective inhibitor of collector is the optimization of fluorite flotation reagents. The research status of low temperature flotation collector and its advantage in the fluorite flotation were mainly introduced to indicate that the main direction of future research should be focused on the development, property and mechanism of combined reagent and new flotation reagents.