Abstract: A polymetallic ore from Jiangxi Province has high content of sulfur, and contains lead, zinc, iron, manganese etc., which could be recovered. Due to the complicated association situation, this paper compared the common differential flotation process and the differential flotation process with the zinc rough concentrate reground and the zinc medium product processed through magnetic separation. Through the comparison, the latter process obtained desired concentrate: the lead concentrate contains 49.57% Pb with the recovery of 87.53%; the zinc concentrate contains 45.82% Zn with a recovery of 75.12%; the sulfur concentrate contains 44.69% S with a recovery of 71.35%. Due to the fact that iron and manganese existed as carbonate in this ore and they always associated with gangue minerals, this paper employs magnetic separation, roasting process and then magnetic separation to recover the iron and manganese in the flotation tailings.