Abstract: Pouring temperature, filling speed, boost pressure and synchronous pressure are filling parameters of counter pressure casting, which have great influence on the filling and solidification process. At the room temperature, the stairs fatigue test was performed at the condition of stress ratio equal to 0.1. The Taguchi method was used to investigate the relationship between the fatigue performance and filling parameters. Results show that the value of fatigue strength with 1.0 ×10⁶ cycle times variables with the filling parameters from 115 MPa to 166 MPa. Filling speed is the most significant factor among the four parameters. Effects of boost pressure, pouring temperature and synchronous pressure on the fatigue strength decrease successively.