Abstract: In light of the problems existing in the Ma Luping Mine，such as the incomplete ventilation system, low ventilation efficiency etc. , different optimization schemes for completing return system are put forward, and the best solution is determined by comparing economic and technical indicators. The feasibility of optimization scheme is theoretically analyzed and evaluated by the three-dimensional simulation of Ventsim software. Incomplete return system and low ventilation efficiency are effectively solved after optimization of ventilation system, and the ventilation economic and technical indicators are significantly improved with the reasonable, effective and stable operation of ventilation system.