Abstract: In light of the characteristics of a high iron Cu-S ore, under the condition of < 75μm grinding fineness being 70 %, using sodium carbonate as pH adjusting agent, with butyl xanthate and ammonium butyl as the combination collector of copper sulfide mixed flotation, iron is recovered from magnetic flotation tailings after the copper sulfide crude concentrate is regrinded to < 45 μm which accounts for 85 %, with DT-2^# The active ingredient is Ca (ClO)₂as the new inorganic inhibitor of pyrite to separate copper and sulfide. The test results show that using the process of "copper sulfide mixed flotation-crude concentrate regrinding-copper sulfide separation-magnetic flotation tailings", copper concentrate, sulfur concentrate and iron concentrate can be obtained containing 22.36 % of Cu with copper recovery rate of 87.29 %, 38.43 % of S with sulfur recovery rate of 62.88 %, and 66.98 % of Fe and iron recovery rate of 91.34 % respectively from a feed ore containing 0.52 % Cu, 2.31 % S and 49.26 % Fe. The process is simple to use with a good beneficiation index.