Abstract: The paper mainly studies the Portland cement clinker prepared by using lead-zinc tailings as raw material， under the condition of different tailings dosages and the same temperature at 1 350 OC . The f -CaO content is tested by the glycerol alcohol method and the compressive strength and flexural strength are measured according to cement mortar strength detection method (ISO). Phase composition， chemical composition and microstructure of clinkers are characterized by using XRD and SEM. The results show that the f-CaO content is at its lowest of 0.07 % when the dosage of lead-zinc tailings is 12.25 %. The cement strength at various ages exceed the requirement of 42.5 standard cement in accordance with GB175 -2007 when the content of lead -zinc tailings is between 12.25 % and 16 % . And when the content of lead -zinc tailings is 12.25 % ， the compressive strengths at 3 days and 28 days are 21.8 MPa and 51.3 MPa， respectively. After mixing proper content of lead-zinc tailings， the main clinker mineral is C₃S with silicate crystals well formed.