Abstract: This paper describes the grinding optimization of a fragile, brittle tungsten polymetallic ore. According to the laboratory conditions test, the laboratory grinding conditions of filling rate of 45 %, grinding time of 4 min, grinding concentration of 67 %, ratio of speed 200 r/min, precision ball diameter: Φ50∶Φ40∶Φ30 = 25 %∶25 %∶50 % were obtained. Then verified by precision experiments under the above conditions, the interval of 19~74 μm is the highest grade which is in line with the range of dissemination size and dissociation for tungsten ore, the interval of -10 μm metal distribution is decreased than that of the site. The characteristics of particle size and metal distribution of the grinding product are improved comprehensivly.