Abstract: Copper zinc sulfide ore has been hard to be separated due to similar floatability, easy activation of Cu²⁺ with sphalerite and some other reasons. The separation is a major problem in mineral processing. The paper studies the copper zinc sulfide ore flotation separation, and describes the status of copper -zinc separation about separation technology, pharmaceutical, and theoretical research. The result shows that with the development of research, copper zinc sulfide ore separation process and reagents have been greatly developed, and new technology and new pharmaceutical continues to emerge. Column flotation method has particularly been applied in the copper-zinc separation because its easily controllable operation and energy efficiency. So it is imperative to strengthen the theoretical study of copper -zinc separation and continue to develop new techniques, new pharmaceutical.