Abstract: In the high - alkaline high calcium environment pyrite was strongly inhibited, that cause difficulties for the recovery of the follow-up of pyrite. In the process of looking for new activator should be noted that its ability to clear the mineral surface hydrophilic membrane composed of CaO, CaSO₄, Ca（OH）₂,Fe（OH）₃, etc, the new activator should also be environmentally friendly, cheap, and a wide source and chemically stable product. The article mainly summarized pyrite activator species,the activation mechanism and practical applications of activated of the inhibited pyrite research.